Cajun chicken pasta bake

Featured in: Homemade Comforts

This dish features tender chicken pieces seasoned with bold Cajun spices, simmered in a creamy sauce with garlic, onions, and bell peppers. It’s combined with penne pasta and three kinds of melted cheese, then baked until golden and bubbly, resulting in a comforting, flavorful casserole perfect for gatherings or family dinners.

Updated on Sat, 15 Nov 2025 11:33:00 GMT
Cajun Chicken Pasta Bake, hot and cheesy, with tender pasta and a creamy, spicy sauce. Save
Cajun Chicken Pasta Bake, hot and cheesy, with tender pasta and a creamy, spicy sauce. | oventhyme.com

A vibrant comforting casserole featuring tender chicken spicy Cajun seasonings creamy sauce and melty cheese all baked with pasta for a crowd-pleasing meal.

I remember the first time I made this for my friends – the kitchen was filled with the aroma of roasting peppers and bubbling cheese. Everyone went back for seconds and it became an instant family favorite.

Ingredients

  • Chicken breasts: 2 large cut into bite-sized pieces
  • Red bell pepper: 1 diced
  • Yellow bell pepper: 1 diced
  • Red onion: 1 small diced
  • Garlic: 2 cloves minced
  • Pasta: 300 g (10 oz) penne or rigatoni
  • Olive oil: 2 tbsp
  • Butter: 1 tbsp
  • Heavy cream: 200 ml (3/4 cup)
  • Milk: 120 ml (1/2 cup)
  • Mozzarella cheese: 100 g (1 cup) shredded
  • Parmesan cheese: 50 g (1/2 cup) grated
  • Cheddar cheese: 100 g (1 cup) shredded
  • Cajun seasoning: 1 1/2 tbsp plus extra for garnish
  • Smoked paprika: 1/2 tsp
  • Salt: 1/2 tsp
  • Black pepper: 1/4 tsp
  • Chili flakes: 1/4 tsp optional for extra heat
  • Fresh parsley: 2 tbsp chopped for garnish

Instructions

Preheat Oven:
Preheat your oven to 200°C (400°F)
Cook Pasta:
Cook the pasta in salted boiling water 2 minutes less than package instructions Drain and set aside
Cook Chicken:
In a large skillet heat olive oil and butter over medium-high heat Add chicken 1 tbsp Cajun seasoning salt and pepper Sauté until browned and cooked through about 6–8 minutes Remove chicken and set aside
Cook Vegetables:
In the same skillet add onions and bell peppers Cook for 4–5 minutes until softened Add garlic smoked paprika and chili flakes (if using) and sauté for 1 minute
Make Sauce:
Reduce heat to medium Pour in cream and milk stirring to scrape up any browned bits Simmer for 2–3 minutes
Add Cheese:
Add 3/4 of the mozzarella cheddar and Parmesan to the sauce Stir until melted and smooth
Combine:
Return the chicken to the skillet then add the cooked pasta Toss everything together to coat well Adjust seasoning as needed
Transfer & Top:
Transfer mixture to a lightly greased baking dish Sprinkle remaining cheeses over the top
Bake:
Bake for 18–20 minutes until cheese is golden and bubbly
Garnish:
Garnish with chopped parsley and a pinch of Cajun seasoning before serving
A bubbling baking dish features golden-brown Cajun Chicken Pasta Bake, ready for a delicious dinner. Save
A bubbling baking dish features golden-brown Cajun Chicken Pasta Bake, ready for a delicious dinner. | oventhyme.com

This dish is a favorite at our family get-togethers – everyone gathers at the table as the cheesy pasta bake comes bubbling out of the oven and it never lasts long

Serving Suggestions

Serve hot straight from the oven with a simple side salad crusty bread or a glass of iced tea or white wine

Variations

Try swapping chicken for turkey or adding sautéed mushrooms spinach or even broccoli for extra veggie power

Storage & Reheating

Leftovers keep well in an airtight container in the fridge for up to 3 days and reheat easily in the oven or microwave until piping hot

Imagine the amazing flavors: steaming Cajun Chicken Pasta Bake, topped with bubbly, melted cheese. Save
Imagine the amazing flavors: steaming Cajun Chicken Pasta Bake, topped with bubbly, melted cheese. | oventhyme.com

This delicious Cajun chicken pasta bake is the perfect comfort food for any night of the week ready to gather everyone around your table

Kitchen Guide

What type of cheese is best for this dish?

Mozzarella, cheddar, and Parmesan cheeses blend well, providing creamy, melty texture and rich flavor.

Can I use a different pasta shape?

Penne or rigatoni work best as they hold sauce well, but any medium pasta shape can be used.

How spicy is the dish?

The Cajun seasoning adds moderate heat, balancing smoky paprika and optional chili flakes for extra kick.

Can I prepare the dish ahead of time?

Yes, assemble the mixture and refrigerate before baking. Bake fresh before serving for best results.

What sides pair well with this casserole?

Light salads, garlic bread, or steamed vegetables complement the rich, hearty flavors nicely.

Cajun chicken pasta bake

Spicy Cajun-seasoned chicken combined with creamy cheese sauce and baked pasta for a flavorful main dish.

Prep duration
20 min
Kitchen time
35 min
Complete duration
55 min
Created by Grace Mitchell


Skill level Medium

Heritage American (Cajun-inspired)

Output 4 Portions

Dietary requirements None specified

What you'll need

Meats

01 2 large chicken breasts, diced

Vegetables

01 1 red bell pepper, diced
02 1 yellow bell pepper, diced
03 1 small red onion, diced
04 2 garlic cloves, minced

Pasta

01 10 ounces penne or rigatoni pasta

Sauces & Dairy

01 2 tablespoons olive oil
02 1 tablespoon butter
03 3/4 cup heavy cream
04 1/2 cup milk
05 1 cup shredded mozzarella cheese
06 1/2 cup grated Parmesan cheese
07 1 cup shredded cheddar cheese

Spices & Seasonings

01 1 1/2 tablespoons Cajun seasoning, plus extra for garnish
02 1/2 teaspoon smoked paprika
03 1/2 teaspoon salt
04 1/4 teaspoon black pepper
05 1/4 teaspoon chili flakes (optional)

Garnish

01 2 tablespoons chopped fresh parsley

Method

Phase 01

Preheat oven: Set oven temperature to 400°F (200°C).

Phase 02

Cook pasta: Boil pasta in salted water, cooking for 2 minutes less than package instructions. Drain and set aside.

Phase 03

Sauté chicken: Heat olive oil and butter in a large skillet over medium-high heat. Add diced chicken, 1 tablespoon Cajun seasoning, salt, and pepper. Cook until browned and cooked through, about 6 to 8 minutes. Remove from skillet.

Phase 04

Cook vegetables: In the same skillet, add diced onions and bell peppers. Cook for 4 to 5 minutes until softened. Stir in garlic, smoked paprika, and chili flakes if using, cooking for an additional minute.

Phase 05

Prepare sauce: Reduce heat to medium and pour in cream and milk. Stir to release browned bits from skillet and simmer for 2 to 3 minutes.

Phase 06

Melt cheeses: Add three-quarters of the mozzarella, cheddar, and Parmesan cheeses to the sauce. Stir until fully melted and smooth.

Phase 07

Combine chicken and pasta: Return chicken to the skillet, add cooked pasta, and toss to combine thoroughly. Adjust seasoning with additional Cajun spice, salt, or pepper if desired.

Phase 08

Transfer to baking dish: Grease a baking dish lightly and transfer the pasta mixture into it. Sprinkle remaining cheeses evenly over the top.

Phase 09

Bake: Bake uncovered for 18 to 20 minutes, or until the cheese topping is golden and bubbling.

Phase 10

Garnish and serve: Sprinkle chopped parsley and a pinch of Cajun seasoning over the dish before serving.

Kitchen tools needed

  • Large skillet or sauté pan
  • Medium saucepan
  • Baking dish (approximately 2 quarts)
  • Wooden spoon
  • Chef's knife and cutting board

Allergy notes

Always review ingredients for potential allergens and seek professional medical advice when uncertain.
  • Contains milk products (cheese, cream, butter) and wheat (pasta).
  • May contain gluten due to pasta choice and potential cross-contamination in spice blends.

Nutrition breakdown (per portion)

Values shown are estimates only - consult healthcare providers for specific advice.
  • Energy: 670
  • Fats: 32 g
  • Carbohydrates: 56 g
  • Proteins: 40 g